What Makes the Bioactive Lipids Phosphatidic Acid and Lysophosphatidic Acid So Special?
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چکیده
منابع مشابه
What makes the bioactive lipids phosphatidic acid and lysophosphatidic acid so special?
Phosphatidic acid and lysophosphatidic acid are minor but important anionic bioactive lipids involved in a number of key cellular processes, yet these molecules have a simple phosphate headgroup. To find out what is so special about these lipids, we determined the ionization behavior of phosphatidic acid (PA) and lysophosphatidic acid (LPA) in extended (flat) mixed lipid bilayers using magic an...
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Phosphatidic acid or 1,2-diacyl-sn-glycero-3-phosphate is not an abundant lipid constituent of any living organism to my knowledge, but it is extremely important as an intermediate in the biosynthesis of triacylglycerols and phospholipids and as a signalling molecule. Indeed, it is often over-estimated in tissues as it can arise by inadvertent enzymatic hydrolysis during inappropriate storage o...
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The formation of phosphatidic acid (PA) from lysophosphatidic acid (LPA), diacylglycerol, or phosphatidylcholine plays a key role in the regulation of intracellular membrane fission events, but the underlying molecular mechanism has not been resolved. A likely possibility is that PA affects local membrane curvature facilitating membrane bending and fission. To examine this possibility, we deter...
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Phosphatidic acid has been given a key position in the scheme of animal lipid metabolism because of its ability to serve as a presursor of a variety of animal lipids. The recent reports of the biosynthesis of phosphatidylserine and phosphatidylglycerol (1, 2) in Escherichia coli and other bacteria suggest that phosphatidic acid (in the coenzyme form, cytidine diphosphate diglyceride) will also ...
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ژورنال
عنوان ژورنال: Biochemistry
سال: 2005
ISSN: 0006-2960,1520-4995
DOI: 10.1021/bi0518794